Abstract:
Background: Human papilloma virus vaccination is a well-known global strategy for the prevention of
cervical cancer. However, uptake of the vaccine varies between regions and countries of the world due to
several factors. Although adolescents are at risk for cervical cancer, there are limited studies measuring
vaccination uptake of female adolescents in the study area.
Objective: The main Objective of the study was to assess human papilloma virus vaccination uptake and
associated factors among 14-19 years school female adolescents in Guduru District, Horo Guduru
Wollega, Oromia, Ethiopia, 2024.
Methods: School-based mixid cross-sectional study design was conducted from April 1-30, 2024 at
selected schools of Guduru district. The collected data was coded and entered using EPI Data version 3.1
and analysis was done by using Statistical Package for Social Science (SPSS)version 27. Binary logistic
regression was used by using the odds ratio with a 95% confidence interval. Variables with a p value<0.25 in the bi-variable analysis was taken into multi-Variables analysis. Finally,a p-value <0.05was
declared statistically significant. The qualitative findings were analysed manualy with thematic analysis.
Result: The study revealed that the magnitude of human papillomavirus vaccination uptake was
166(39.43%)(95% CI:34.8% to 44.2%). Of this,105(24.9%)had received one dose and 61(14.5%) had
received two doses. Factors siginificantly associated with human papilloma virus vaccination uptake
were: Having information prior to vaccination(AOR=4.04,95%CI:2.01-8.09), respondents level of
education(AOR=0.62,95%CI:0.62-0.90),Participats‟mothers level of education(AOR=11.61,95%CI:
(2.24-26.07), Ever heard about human papillomavirus infection before(AOR=0.13,95%CI:0.05-0.34),
living together with parents(AOR=0.19,95%CI:(0.06-0.67)were statistically siginificant with huma
papilloma virus vaccination uptake. In addition to this, lack of information, mis-understanding, fear of
injection were major barriers of identified by qualitative finding.
Conclusion and Recommendation: In this study finding, the magnitude of human papillomavirus
vaccination uptake was low. Having information prior, respondents and their mothers level of education,
ever heard about human papillomavirus infection before and vaccination is used to prevent human
papillomavirus infection were statistically significant with human papillomavirus vaccine uptake. Hence,
massive school female adolescent and community sensitization is needed to improve the vaccine uptake.
