Abstract:
Background: Diabetes is a serious, chronic condition that occurs when raised level of blood 
glucose occur because the body cannot produce any or enough of the hormone insulin or cannot 
effectively use the insulin it produces. 
Objective: To assess the health related quality of life and associated factors among patients with 
diabetes on follow up at wolkite university specialized hospital south west Ethiopia.
Method: An institutional-based cross-sectional study design was conducted on 420 patients from 
June 24 to August 25, 2023, and a systematic random sampling technique was used. A 
WHOQOL-BREF, a 26-item questionnaire, was used to measure the outcome variable. The data 
was coded and entered in the Epi Data entry form, and then exported into SPSS version 23 for 
analysis. A binary logistic regression with a p-value of < 0.25 was included in a multivariable 
logistic regression analysis. The next multivariable logistic regression analysis was done, and 
variables with P-values of < 0.05 were considered statistically significant at a CI of 95%, and 
AOR was used for the interpretation of the strength of the association of the independent 
variables. The final model was tested for its goodness of fit using Hosmer and Lemeshow's. 
Results: The study included a total of 400 individuals with diabetes, giving a response rate of 
92.5% and 210 (52.5%) had a good HRQOL. Being male (AOR 4.3, 95%CI: 2.34, 7.95), being 
married (AOR 3.2, 95%CI: 1.78, 5.79) and being educated (AOR 0.04; 95%CI: 0.01, 0.14) were 
positively associated with good health related quality of life. Furthermore, absence of diabetic 
complications (AOR 4.01, 95%CI: 1.94, 8.42), and absence of comorbidity (AOR 5.1; 95%CI: 
2.89, 9.02) had positive relationship with good health related quality of life.
Conclusion: More than half of adult diabetic patients had a good health-related quality of life. 
Being male, married, educated and absence of co-morbidity and complications are significantly 
associated with a good health-related quality of life.
Recommendation: The health professional should use a holistic approach to management 
during follow-up, especially for those patients who have comorbidity, are unmarried, are 
developing complications, no formal education, to improve their health related quality of life.