Precancerous Cervical Lesion And Associated Factors Among Women On Antiretroviral Treatment At Dukem Health Center, Dukem Town,Oromia, Ethiopia,2022

Abstract

Background: Cervical cancer is a global public health problem and the second most common cancer-causing morbidity and mortality among women in developing countries. Women who have been infected with human immunodeficiency virus are more prone to developing cervical lesions. Objective: To assess the prevalence and associated factors of precancerous cervical lesions among women on antiretroviral therapy at Dukem Health Center, Oromia, Ethiopia. Methods: An institution based cross sectional study was conducted among 257 women on antiretroviral treatment. The study participant was selected using simple random sampling. Data was collected using pretested structured questionnaire, medical record review and visual inspection with acetic acid was done for study participants to detect precancerous cervical cancer lesions. Collected data was entered into Epi-info 7.4 and exported to SPSS version 20 for analysis. Descriptive statistics were used to determine the level of precancerous cervical lesions and characteristics of study participants. Binary logistic regression and multivariable logistic regression analysis were used to identify presence and strength of association with precancerous cervical lesions. In multivariable logistic regression analysis, significant declared at variables with P-value < 0.05 with 95% CI of the adjusted odd ratio (AOR). Results: The prevalence of precancerous cervical lesions was 16% (95% CI; 11.7-20.6). Women with a history of sexually transmitted infections were [AOR = 4.30; 95% CI (1.48– 12.49)], women who used oral contraceptives were [AOR = 6.56; 95% CI (2.10-20.50)], and women who two or more life time’s sexual partner were 2.53 times more likely to have precancerous cervical lesions than those who had single sexual partners [AOR = 2.53; (95% CI (1.05, 6.101)]. Conclusion: The proportion of precancerous cervical lesions was found to be high in this study. Using oral contraceptives pills, having a history of STI, having two or more life time sexual partners, and recent CD4 count less than 200cells/mm3 were all associated with precancerous cervical cance